Genetically Modified Beagle Glows

Lee is director of the Seoul National University Hospital for Animals in Korea and a professor in the Department of Theriogenology and Biotechnology.

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He and his colleagues achieved the feat using a five-step process. The scientists first inserted a DNA fragment that controls the expression of a green fluorescent gene into dog cells. They next extracted DNA from a dog oocyte (an immature female reproductive cell prior to fertilization) and injected the fluorescent-modified dog cells into it.

The third step was to use a process known as Somatic Cell Nuclear Transfer to generate an embryo. The resulting embryo was then transferred into a surrogate dog mother. After 60 days of pregnancy, she gave birth to Tegon. When given a doxycycline antibiotic, the female beagle literally glows under UV light.

Medical research teams such as Lee's are creating these animals in hopes of improving studies to benefit humans. Lee's process improves upon the earlier work, since it permits better control over the animal's glow.

Dogs are targeted for specific reasons.

"The dog has 268 genetic type diseases that are similar to those of humans," Lee explained. "Also, the dog has physiological and anatomical similarities with humans. These reasons make them a good model for human disease."

Lee said the genes injected to make the dog glow could be substituted with genes that trigger fatal diseases. He and his team would then be able to chart the course of Alzheimer's, Parkinson's and more, better understanding how such diseases develop.

Dogs also make good candidates for this kind of research because they have "good communication skills with humans, which enable them to have good response skills to direct orders. They are also easy to handle." He added, "Compared to mice and other smaller animals, dogs provide a much larger sample collection."

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He said that dogs are not harmed in any way by the fluorescence-adding process.

Chemyong Jay Ko, an associate professor in the College of Health Sciences at the University of Kentucky, told Discovery News that dogs "have long been used as one of the prime animal models in the field of medical research."

He explained that they are used to test new drugs for their effectiveness, toxicology and dosage before the medications are administered to humans.

Canine Anatomy Book

Canine Anatomy Book

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Canine Muscular Anatomy Chart

Canine Internal Organ Anatomy Chart

Canine Skeletal System Anatomical Chart

Anatomy & pathology, the world's best anatomical charts

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